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Use the lowest effective dosage for the shortest possible durationAvoid administration of more than one NSAID at a timeAvoid use in patients at higher risk unless benefits are expected to outweigh the increased risk of bleedingFor such patientsas well as those with active GI bleedingconsider alternate therapies other than NSAIDsRemain alert for signs and symptoms of GI ulceration and bleeding during NSAID therapyIf a serious GI adverse event is suspectedpromptly initiate evaluation and treatmentand discontinue CELEBREX until a serious GI adverse event is ruled outIn the setting of concomitant use of low-dose aspirin for cardiac prophylaxismonitor patients more closely for evidence of GI bleedingsee DRUG INTERACTIONS
Celecoxib produced no evidence of delayed labor or parturition at oral doses up to 100 mg/kg in ratsapproximately 7-fold human exposure as measured by the AUC0-24 at 200 mg twice dailyThe effects of CELEBREX on labor and delivery in pregnant women are unknown.
For ASthe dosage of CELEBREX is 200 mg daily in singleonce per dayor dividedtwice per daydosesIf no effect is observed after 6 weeksa trial of 400 mg daily may be worthwhileIf no effect is observed after 6 weeks on 400 mg dailya response is not likely and consideration should be given to alternate treatment options.
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since cross reactivity, including bronchospasm, between aspirin and other nonsteroidal anti-inflammatory drugs has been reported in such aspirin-sensitive patients, celebrex should not be administered to patients with this form of aspirin sensitivity and should be used with caution in patients with preexisting asthma.